Normal Peripheral Blood Cells

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Authors: Jean Tatum, MT(ASCP); Karen Hay, MT(ASCP) M.S.
Reviewer: Leah Coppolino, MPH, MLS(ASCP)

This course covers the basics of normal peripheral blood cell morphology, including appearance, kinetics, and function of red blood cells, leukocytes, and platelets. It is assumed that students have a basic knowledge of the principles of cell morphology, and of preparation and staining of a Wright's stained peripheral blood smear.

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Continuing Education Credits

Objectives

  • Discuss the characteristics of leukocytes, erythrocytes, and thrombocytes that are normally present in peripheral blood.
  • Compare and contrast the nuclear and cytoplasmic characteristics of each of the normal peripheral blood cells.
  • Evaluate the roles and functions of normal peripheral blood cells.
  • Based on knowledge obtained from this course, identify images of the various types of normal peripheral blood cells.

Course Outline

  • Introduction to Peripheral Blood Cells
      • The Cellular Components of Blood
      • Red Blood Cells (RBCs)
      • White Blood Cells (WBCs)
      • Platelets
      • Identifying Peripheral Blood Cells
      • Which peripheral blood cell is involved in the body's defense against infection?
  • Glossary
      • Glossary of Terms A through M.
      • Glossary of Terms N through Z.
  • Appearance of Granulocytes
    • Neutrophils
      • Introduction to Segmented and Band Nuclei
      • Appearance of a Band Neutrophil
      • Maturing into Segmented Neutrophil
      • Segmented Neutrophils
      • Differentiating Bands from Segs
      • Which of the following is the more immature cell?
      • What is the characteristic that distinguishes a segmented neutrophil from a band neutrophil?
    • Eosinophils
      • Eosinophils
      • Difference Between Eosinophilic Granules and Neutrophilic Granules
      • The Nucleus of a Eosinophil
      • All of the following statements describe a mature eosinophil EXCEPT:
    • Basophils
      • Basophils
      • Basophil Granules and Chromatin Pattern
    • Name that Cell
      • Identify the nucleated blood cell:
      • Identify the nucleated blood cell:
      • Identify the nucleated blood cell that is indicated by the arrow:
      • Identify the nucleated blood cell:
      • Identify the nucleated blood cell:
      • Identify the nucleated blood cell:
  • Function & Kinetics of Granulocytes
      • Primary Function of Neutrophils
      • Primary Function of Neutrophils, continued
      • Eosinophil Function and Lifespan
      • Basophil Function and Lifespan
      • Eosinophils are increased in all of the following conditions EXCEPT:
      • During phagocytosis the neutrophilic granules release digestive enzymes into the vacuole containing a microorganism to kill or destroy the phagocytize...
      • Basophils' primary role involves:
  • Appearance of Mononuclear Cells
      • Mononuclear Cells: Lymphocytes and Monocytes.
    • Lymphocytes
      • Lymphocytes
      • Large Lymphocytes and Reactive Lymphocytes
      • The nucleus of a small lymphocyte is about the same size as a:
      • Which of the following cells is characterized by a thin rim of cytoplasm around the nucleus?
    • Monocytes
      • Monocyte Appearance
      • Differentiating Monocytes from Large Lymphocytes
      • Differentiating Monocytes from Large Lymphocytes: Table.
      • All of the following descriptions are characteristic of monocytes EXCEPT:
    • Name that Cell
      • Identify the nucleated blood cell that is indicated by the arrow:
      • Identify the nucleated blood cell:
      • Identify the nucleated blood cell:
      • Identify the nucleated blood cell:
  •  Function and Kinetics of Mononuclear Cells
      • What is the Function of Lymphocytes?
      • Natural Killer (NK) Cells
      • Monocytic Function
      • T lymphocytes are larger and have more vacuoles than B lymphocytes.
      • Match the following cells with their corresponding characteristics:
      • Match the following cells with their corresponding characteristics:
      • Where is the main site of action for monocytes after diapedesis?
  • Appearance, Function and Kinetics of Platelets
      • Platelet Appearance
      • Platelet Clumps
      • Platelet Kinetics
      • Platelet Function
      • All of the following statements describe a method by which platelets aid coagulation EXCEPT:
  • Appearance, Function and Kinetics of Erythrocytes
      • Appearance of the Erythrocyte (Red Blood Cells)
      • Erythrocyte (RBC) Function and Kinetics
  • Name that Cell Review
      • Identify the nucleated blood cell:
      • Identify the nucleated blood cell:
      • Identify the nucleated blood cell:
      • Identify the nucleated blood cell:
      • Identify the nucleated blood cell:
      • Identify the nucleated blood cell:
  • References
      • References

Additional Information

Level of instruction: Basic

Intended Audience: Clinical Laboratory Science students and medical technologists and technicians seeking review or continuing education. It is also appropriate for medical students who are first encountering peripheral blood morphology.

Course Description: This course covers the basics of normal peripheral blood cell morphology, including appearance, kinetics, and function of red blood cells, leukocytes, and platelets. It is assumed that students have a basic knowledge of the principles of cell morphology, and of preparation and staining of a Wright's stained peripheral blood smear.

About the Course: This course is part of a series of courses adapted for the web by MediaLab, under license from Education Materials for Health Professionals, Inc. Dayton OH, 45420. Copyright EMHP.
 
Reviewer Information: Leah Coppolino, MPH, MLS(ASCP) is a Program Director at MediaLab, Inc. Previously, she was the Director of the Medical Laboratory Science Program at St. Christopher’s Hospital for Children in Philadelphia, Pennsylvania. She holds a Masters in Public Health from Thomas Jefferson University.

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