Common Coagulopathies

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Author: Kevin F. Foley PhD, MT, DABCC
Reviewer: Rory Huschka, M.Ed., MT(ASCP) & Laurie Bjerklie, M.Ed., MT(ASCP)

This course addesses common coagulopathies and the laboratory testing used to diagnose and evaluate these disorders. Hemophilia A and B, Disseminated Intravascular Coagulation, VonWillebrand disease, and the Factor V Leiden mutation are explored. Lupus anticoagulants are discussed along with how they can be mitigated in laboratory analysis.

Continuing Education Credits


  • Explain the cause of Hemophilia A and B and describe the testing used to evaluate these conditions.
  • Describe the symptoms of Disseminated Intravascular Coagulation (DIC) and the laboratory testing used to help diagnose it.
  • Describe the prevalence, pathology, and lab testing used to assess the Factor V Leiden mutation.
  • Describe the different forms of Von Willebrand disease and the platelet testing used to assess this condition.
  • Explain what a lupus anticoagulant is and how this interference can be identified and mitigated.

Course Outline

  • Coagulopathies
      • Introduction
  • Hemophilia
      • Hemophilia
      • Hemophilia A
      • Factor Activity Assays
      • Lab Interference
      • Hemophilia B
      • Which is true of a patient who has a prolonged aPTT and a factor VIII activity assay of <5%?
      • Emicizumab is relevant to the lab for which of the following reasons?
  • Disseminated Intravascular Coagulation
      • Fibrinolysis
      • Measuring Fibrinolysis
      • What is DIC?
      • Diagnosing Disseminated Intravascular Coagulation (DIC)
      • Lab Results in DIC
      • Which of the following would NOT be expected in a patient with DIC?
      • Which of the following is true concerning fibrinolysis?
  • Hyper-coagulable Conditions
      • Thromboembolism
      • Protein C and S
      • Protein C and S Resistance
      • Testing for APC Resistance and Factor-V-Leiden
      • Which of the following is true concerning Protein S and Protein C?
      • A DVT is:
  • Von Willibrand's Disease
      • What is Von Willibrand's Disease?
      • Types of VWD
      • Testing for VWD
      • Testing for VWD (Continued)
      • Testing for VWD (Continued)
      • Which of the following is true?
      • Which of the following tests is NOT used in the work-up of VWD?
  • Lupus Anticoagulant
      • What is a Lupus Anticoagulant (LAC)?
      • APS versus LAC
      • Testing for LAC
      • A dRVVT that corrects with normal donor plasma suggests:
      • Antiphospholipid syndrome is a hyper-coagulable state caused by the presence of antibodies against phospholipids or phospholipid-binding proteins.
  • References
      • References

Additional Information

Level of instruction: Intermediate

Intended Audience: Medical technologists, medical technology students, and those interested in reviewing the fundamentals of coagulation.

Author Credentials:   Kevin F. Foley, PhD, DABCC, MT, SC is the director of clinical pathology for the Kaiser Permanente Northwest region. He also teaches clinical chemistry at Oregon Health Sciences University. Dr. Foley earned his PhD in clinical pharmacology and toxicology at East Carolina School of Medicine in North Carolina. He recieved a PhD in clinical pharmacology and toxicology from Brody School of Medicine, Greenville, NC. He has been working in laboratory medicine for over 15 years, starting his career as a medical technologist.

Reviewer Credentials: Rory Huschka, M. Ed., MT(ASCP), has over 20 years of experience as a medical technologist, technical supervisor, professor, and manager. He is the former Director of Clinical Laboratory Science and Medical Laboratory Technician Programs at Brookline College. He is currently a Program Director at MediaLab, Inc. Rory holds a BS degree in Medical Technology from North Dakota State University and a Masters in Educational Leadership from Argosy University.
Laurie Bjerklie, M.Ed., MT(ASCP), is currently a professor at Rasmussen College in Fargo, ND for their MLT program where she teaches a variety of courses including hematology and microbiology. She is the former Program Director of the Clinical Laboratory Science program at DeVry University in Phoenix, Arizona. Bjerklie has over ten years of experience in higher education and continues to work part time as a bench tech. 

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This course is part of:
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