Common Coagulopathies

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Author: Kevin F. Foley, PhD, MLS(ASCP)SC, DABCC
Reviewer: Laurie Bjerklie, MA, MLS(ASCP)^CM

This course addesses common coagulopathies and the laboratory testing used to diagnose and evaluate these disorders. Hemophilia A and B, Disseminated Intravascular Coagulation, VonWillebrand disease, and the Factor V Leiden mutation are explored. Lupus anticoagulants are discussed along with how they can be mitigated in laboratory analysis.

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Continuing Education Credits

P.A.C.E.® Contact Hours: 1 hour(s)
Florida Board of Clinical Laboratory Science CE Credit Hours -
General (Hematology): 1 hour(s)

Objectives

Explain the cause of Hemophilia A and B and describe the testing used to evaluate these conditions.
Discuss the symptoms of Disseminated Intravascular Coagulation (DIC) and the laboratory testing used to help diagnose it.
Describe the prevalence, pathology, and lab testing used to assess the Factor V Leiden mutation.
Describe the different forms of von Willebrand's disease and the platelet testing used to assess this condition.
Explain what a lupus anticoagulant is and how this interference can be identified and mitigated.

Course Outline

Coagulopathies

Introduction

Hemophilia

Hemophilia
Hemophilia A
Factor Activity Assays
Lab Interference
Hemophilia B
Which is true of a patient who has a prolonged aPTT and a factor VIII activity assay of <5%?
Emicizumab is relevant to the lab for which of the following reasons?

Disseminated Intravascular Coagulation

Fibrinolysis
Measuring Fibrinolysis
What is Disseminated Intravascular Coagulation?
Diagnosing Disseminated Intravascular Coagulation
Lab Results in DIC
Which of the following would not be expected in a patient with DIC?
Which of the following is true concerning fibrinolysis?

Hypercoagulable Conditions

Thromboembolism
Protein C and S
Protein C and S Resistance
Testing for APC Resistance and Factor V Leiden
Which of the following is true concerning Protein C and Protein S?
A deep vein thrombosis is:

Von Willebrand's Disease

What is Von Willebrand's Disease?
Types of VWD
Testing for VWD
Testing for VWD, continued
Testing for VWD, continued
Which of the following is true?
Which of the following tests is not used in the work-up of VWD?

Lupus Anticoagulant

What is a Lupus Anticoagulant?
APS versus LAC
Testing for LAC
A dRVVT that corrects with normal donor plasma suggests:
True or False: Antiphospholipid syndrome is a hypercoagulable state caused by the presence of antibodies against phospholipids or phospholipid-binding...

References

References

Additional Information

Level of Instruction: Intermediate

Intended Audience: Medical laboratory scientists, medical laboratory technicians, students, and those interested in reviewing the fundamentals of coagulation.

Author Information: Kevin F. Foley, PhD, MLS(ASCP)SC, DABCC is the director of clinical pathology for the Kaiser Permanente Northwest region. He also teaches clinical chemistry at Oregon Health Sciences University. Dr. Foley earned his PhD in clinical pharmacology and toxicology at the East Carolina School of Medicine in North Carolina. He received a PhD in clinical pharmacology and toxicology from Brody School of Medicine, Greenville, NC. He has been working in laboratory medicine for over 15 years, starting his career as a medical laboratory scientist.

Reviewer Information: Laurie Bjerklie, MA, MLS(ASCP)^CM is currently an Education Developer for MediaLab and LabCE. She earned a B.S. in Medical Laboratory Science from the University of North Dakota and an M.A. in Curriculum and Instruction from Saint Xavier University. She has over 15 years of experience in higher education and has held program director and faculty positions in both MLT and MLS programs.

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Compliance & CE

VWF binds platelets and collagen in the endothelium leading to clot formation.