Myeloproliferative Neoplasms

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Author: Leah Coppolino, MPH, CLS(NCA), MT(ASCP)
Reviewer: Rebecca J. Laudicina, PhD, MLS(ASCP)CM & Rory Huschka, M.Ed., MT(ASCP)

This course describes the 2008 World Health Organization classification system for myeloproliferative neoplasms (MPNs). The different types of MPNs are compared and contrasted based upon etiology and patient symptoms. Hematologic, cytogenetic, and other laboratory features associated with specific MPNs are presented in this course along with a list of common treatment options.

Continuing Education Credits

Objectives

  • Describe the 2008 World Health Organization classification system for myeloproliferative neoplasms (MPNs).
  • Compare and contrast the types of MPNs based upon etiology and patient symptoms.
  • Discuss the hematologic, cytogenetic, and other laboratory features associated with specific MPNs.
  • List common treatment options.

Course Outline

  • Myeloproliferative Neoplasms
      • Introduction to Myeloproliferative Neoplasms (MPNs)
      • Classification of Myeloproliferative Neoplasms (MPNs)
      • Pathophysiology of Myeloproliferative Neoplasms (MPNs)
      • Symptoms
      • Match the myeloproliferative neoplasm with the cell line that is most affected.
    • Chronic Myeloid Leukemia
      • Chronic Myeloid Leukemia (CML)
      • CML and the Philadelphia Chromosome
      • Laboratory Investigation of CML
      • CML Peripheral Blood Smear
      • Progression of CML
      • Treatment of CML
      • The Philadelphia chromosome, associated with chronic myeloid leukemia (CML), involves a reciprocal translocation of genes from which two chromosomes?
    • Chronic Neutrophilic Leukemia
      • Chronic Neutrophilic Leukemia (CNL)
      • Chronic Neutrophilic Leukemia (CNL), continued
    • Hypereosinophilic Syndrome/Chronic Eosinophilic Leukemia
      • Hypereosinophilic Syndrome (HES)
      • Chronic Eosinophilic Leukemia (CEL)
      • What causes the characteristic heart and/or lung damage frequently demonstrated in patients with chronic eosinophilic leukemia?
    • Essential Thrombocythemia
      • Essential Thrombocythemia (ET)
      • Diagnosis of Essential Thrombocythemia (ET)
      • Diagnosis of Essential Thrombocythemia (ET): Bone Marrow Findings
      • Essential Thrombocythemia (ET) Diagnosis
      • ET Treatment
      • Which of the following thrombocytic characteristics are often associated with essential thrombocythemia (ET)?
    • Primary Myelofibrosis
      • Primary Myelofibrosis (PMF)
      • Diagnosis of Primary Myelofibrosis (PMF)
      • Diagnosis of Primary Myelofibrosis: World Health Organization (WHO) Criteria
      • Which of the following red blood cell morphologic features is associated with primary myelofibrosis?
    • Polycythemia Vera
      • Polycythemia Vera (PV)
      • Diagnosis of Polycythemia Vera (PV)
      • Treatment of Polycythemia Vera
      • Which type of anemia can be caused by the common treatment for polycythemia vera, which is used to manage patient symptoms?
    • Myeloproliferative Neoplasm, Unclassifiable (MPN-u)
      • Myeloproliferative Neoplasms, Unclassifiable (MPD-u)
  • Summary
      • Table: Laboratory Findings Associated with Myeloproliferative Neoplasms (MPNs)
  • References
      • References

Additional Information

Level of instruction: Intermediate

Intended Audience: Medical laboratory scientists, medical technologists, and technicians. This course is also appropriate for medical laboratory science students and pathology residents.
 
Author information:  Leah Coppolino, MPH, MLS(ASCP)CM is a Program Director at MediaLab, Inc. Previously, she was the Director of the Medical Laboratory Science Program at St. Christopher’s Hospital for Children in Philadelphia, Pennsylvania. She holds a Masters in Public Health from Thomas Jefferson University.
 
Reviewer information: Rebecca J. Laudicina, PhD, MLS(ASCP)CM is Professor Emeritus in the Division of Clinical Laboratory Science at The University of North Carolina at Chapel Hill’s School of Medicine. She obtained a Master of Education and PhD in Educational Psychology from Temple University. She is the author of numerous hematology-related publications.
 
Reviewer information: Rory Huschka, M. Ed., MT(ASCP), has over 20 years of experience as a medical technologist, technical supervisor, professor, and manager. He is the former Director of Clinical Laboratory Science and Medical Laboratory Technician Programs at Brookline College. He is currently a Program Director at MediaLab, Inc. Rory holds a BS degree in Medical Technology from North Dakota State University and a Masters in Educational Leadership from Argosy University.   He has also completed the Six Sigma Green Belt training at Villanova University.  

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