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Continuing Education Credits

  • P.A.C.E.® Contact Hours: 2 hour(s)
  • Florida Board of Clinical Laboratory Science CE - General (Blood Banking / Immunohematology): 2 hour(s)

Objectives

  • Compare the different types of immune hemolytic anemias.
  • Identify and investigate potential serologic discrepancies caused by autoimmune and drug-induced hemolytic anemias.
  • Differentiate the four mechanisms involved in drug-induced hemolytic anemias.
  • List medications that may be associated with drug-induced hemolytic anemia.

Course Outline

  • Immune Hemolytic Anemias
      • Introduction
      • Direct Antiglobulin Test (DAT)
      • Classification of Hemolytic Anemias
  • Alloimmune Hemolytic Anemia
      • Alloimmune Hemolytic Anemia
  • Autoimmune Hemolytic Anemias
      • Autoimmune Hemolytic Anemia (AIHA): Introduction
      • Symptoms of Autoimmune Hemolytic Anemias
      • Testing for Autoantibodies
      • Possible Serological and Laboratory Presentations
      • True or False: A direct antiglobulin test (DAT) is usually negative in cases of autoimmune hemolytic anemia.
    • Cold Autoimmune Hemolytic Anemia
      • Cold Autoimmune Hemolytic Anemia
      • Cold Hemagglutinin Disease (CHD)
      • Paroxysmal Cold Hemoglobinuria (PCH)
      • PCH Donath-Landsteiner Test
      • ABO/Rh Typing in the Presence of Cold Autoantibodies
      • Laboratory Presentations of Cold Autoantibodies - Antibody ID and Detection
      • In paroxysmal cold hemoglobinuria (PCH), the autoantibody specificity is most commonly anti-I.
      • Cold hemagglutinin disease (CHD) is caused by an IgM antibody with a broad thermal range.
    • Warm Autoimmune Hemolytic Anemia
      • Warm Autoimmune Hemolytic Anemia (WAIHA)
      • Serological Characteristics in WAIHA
      • WAIHA Investigation: Serological Findings Following Elution
      • Possible Scenarios When Transfusions are Needed in the Presence of WAIHA
      • Detection and Identification of An Alloantibody in the Presence of a Warm-Reactive Autoantibody
      • Autologous Adsorption (Autoadsorption)
      • Allogeneic Adsorption
      • Transfusion Considerations for WAIHA
      • Treatment of WAIHA
      • In a case of WAIHA , the production of IgG or IgG and complement that sensitizes the red blood cells leads to red blood cell destruction.
      • Which type of adsorption must be done if a patient has been recently transfused?
    • Mixed-Type Autoimmune Hemolytic Anemia
      • Mixed Type Autoimmune Hemolytic Anemia (AIHA)
  • Drug-Induced Hemolytic Anemia
      • Drug-Induced Immune Hemolytic Anemia Introduction
      • Mechanisms
      • Drug Adsorption Mechanism
      • Immune Complex Mechanism
      • Membrane Modification (Non-Immune Adsorption of Proteins)
      • Induction of Autoimmunity
      • Treatment of Drug-Induced Immune Hemolytic Anemia
      • Laboratory Investigation of Drug-Induced Immune Hemolytic Anemia
      • Which mechanism of drug-induced red cell destruction closely mimics the serologic presentation of warm autoimmune hemolytic anemia (WAIHA)?
      • Which mechanism of drug-induced hemolytic anemia involves the formation of drug-antibody combinations that bind non-specifically to RBC membranes and ...
      • Penicillin is one of the medications that may be responsible for the immune-complex mechanism of drug-induced hemolytic anemia.
  • Case Study
      • Case Study OneA 50-year-old female patient with systemic lupus erythematosus (SLE) is admitted to the hospital with evidence of hemolysis, including d...
      • Case Study One, continued
      • Case Study One, continued
      • Case Study One, continued
      • Case Study One, continuedTo determine the appropriate adsorption technique to use, an accurate transfusion history must be obtained. In this case the ...
      • Case Study One, continued The results of the autoadsorbed serum tested with a set of antibody screen cells are shown on the right. What does the patte...
      • Case Study One Conclusion
  • Case Study
      • Case Study Two
      • Case Study Two, continued
      • Case Study Two, continuedA DAT is ordered on the patient along with an antibody screen. The DAT is positive and the antibody screen is negative. Eluti...
      • Case Study Two, Conclusion
  • References
      • References
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